An engineered nano-plasmonic biosensing surface for colorimetric and SERS detection of DNA-hybridization events

Esmaeil Heydari; David Thompson; Duncan Graham; Jonathan M. Cooper; Alasdair W. Clark

doi:10.1117/12.2076915

11 March 2015 An engineered nano-plasmonic biosensing surface for colorimetric and SERS detection of DNA-hybridization events

Esmaeil Heydari, David Thompson, Duncan Graham, Jonathan M. Cooper, Alasdair W. Clark

Author Affiliations +

Proceedings Volume 9340, Plasmonics in Biology and Medicine XII; 93400O (2015) https://doi.org/10.1117/12.2076915
Event: SPIE BiOS, 2015, San Francisco, California, United States

Abstract

We report a versatile nanophotonic biosensing platform that enables both colorimetric detection and enhanced Raman spectroscopy detection of molecular binding events. Through the integration of electron-beam lithography, dip-pennanolithography and molecular self-assembly, we demonstrate plasmonic nanostructures which change geometry and plasmonic properties in response to molecularly-mediated nanoparticle binding events. These biologically-active nanostructured surfaces hold considerable potential for use as multiplexed sensor platforms for point-of-care diagnostics, and as scaffolds for a new generation of molecularly dynamic metamaterials.

Citation Download Citation

Esmaeil Heydari, David Thompson, Duncan Graham, Jonathan M. Cooper, and Alasdair W. Clark "An engineered nano-plasmonic biosensing surface for colorimetric and SERS detection of DNA-hybridization events", Proc. SPIE 9340, Plasmonics in Biology and Medicine XII, 93400O (11 March 2015); https://doi.org/10.1117/12.2076915

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available