DNA Sequence Analysis By Optical Pattern Recognition

Michael D. Gildner; William A. Christens-Barry; James C. Martin; James F. Hawk

doi:10.1117/12.976598

22 August 1988 DNA Sequence Analysis By Optical Pattern Recognition

Michael D. Gildner, William A. Christens-Barry, James C. Martin, James F. Hawk

Author Affiliations +

Proceedings Volume 0938, Digital and Optical Shape Representation and Pattern Recognition; (1988) https://doi.org/10.1117/12.976598
Event: 1988 Technical Symposium on Optics, Electro-Optics, and Sensors, 1988, Orlando, FL, United States

Abstract

DNA sequence analysis has been demonstrated with optical pattern recognition techniques. New methods to optically study features of the DNA molecular code have been developed by creating new DNA sequence representations. This research involves representing DNA sequences by characters which have been designed so that their Fourier transform properties can be used to perform optical searches for non-specific sequence features. To aid in the design of these characters, a computer simulation of the optical process was developed. Matched spatial filters (MSF) were made of important DNA features using the new DNA representations and searches performed on DNA sequences. The search results were obtained using optical correlation and studied with the aid of image processing capabilities on a microcomputer. Topics to be discussed are DNA features and organization, character design, and optical pattern recognition.

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Michael D. Gildner, William A. Christens-Barry, James C. Martin, and James F. Hawk "DNA Sequence Analysis By Optical Pattern Recognition", Proc. SPIE 0938, Digital and Optical Shape Representation and Pattern Recognition, (22 August 1988); https://doi.org/10.1117/12.976598

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