Fourier-based linear systems description of free-breathing pulmonary magnetic resonance imaging

D. P. I. Capaldi; S. Svenningsen; I. A. Cunningham; G. Parraga

doi:10.1117/12.2081503

17 March 2015 Fourier-based linear systems description of free-breathing pulmonary magnetic resonance imaging

D. P. I. Capaldi, S. Svenningsen, I. A. Cunningham, G. Parraga

Proceedings Volume 9417, Medical Imaging 2015: Biomedical Applications in Molecular, Structural, and Functional Imaging; 94171A (2015) https://doi.org/10.1117/12.2081503
Event: SPIE Medical Imaging, 2015, Orlando, Florida, United States

Abstract

Fourier-decomposition of free-breathing pulmonary magnetic resonance imaging (FDMRI) was recently piloted as a way to provide rapid quantitative pulmonary maps of ventilation and perfusion without the use of exogenous contrast agents. This method exploits fast pulmonary MRI acquisition of free-breathing proton (¹H) pulmonary images and non-rigid registration to compensate for changes in position and shape of the thorax associated with breathing. In this way, ventilation imaging using conventional MRI systems can be undertaken but there has been no systematic evaluation of fundamental image quality measurements based on linear systems theory. We investigated the performance of free-breathing pulmonary ventilation imaging using a Fourier-based linear system description of each operation required to generate FDMRI ventilation maps. Twelve subjects with chronic obstructive pulmonary disease (COPD) or bronchiectasis underwent pulmonary function tests and MRI. Non-rigid registration was used to co-register the temporal series of pulmonary images. Pulmonary voxel intensities were aligned along a time axis and discrete Fourier transforms were performed on the periodic signal intensity pattern to generate frequency spectra. We determined the signal-to-noise ratio (SNR) of the FDMRI ventilation maps using a conventional approach (SNR_C) and using the Fourier-based description (SNR_F). Mean SNR was 4.7 ± 1.3 for subjects with bronchiectasis and 3.4 ± 1.8, for COPD subjects (p>.05). SNR_F was significantly different than SNR_C (p<.01). SNR_F was approximately 50% of SNR_C suggesting that the linear system model well-estimates the current approach.

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D. P. I. Capaldi, S. Svenningsen, I. A. Cunningham, and G. Parraga "Fourier-based linear systems description of free-breathing pulmonary magnetic resonance imaging", Proc. SPIE 9417, Medical Imaging 2015: Biomedical Applications in Molecular, Structural, and Functional Imaging, 94171A (17 March 2015); https://doi.org/10.1117/12.2081503

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KEYWORDS

Signal to noise ratio

Magnetic resonance imaging

Imaging systems

Systems modeling

Chronic obstructive pulmonary disease

Image registration

Fourier transforms

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