20 kHz ultrasound assisted treatment of chronic wounds with concurrent optic monitoring

Christopher R. Bawiec; Youhan Sunny; David Diaz; Sumati Nadkarni; Michael S. Weingarten; Michael Neidrauer; David J. Margolis; Leonid Zubkov; Peter A. Lewin

doi:10.1117/12.2083508

22 May 2015 20 kHz ultrasound assisted treatment of chronic wounds with concurrent optic monitoring

Christopher R. Bawiec, Youhan Sunny, David Diaz, Sumati Nadkarni, Michael S. Weingarten, Michael Neidrauer, David J. Margolis, Leonid Zubkov, Peter A. Lewin

Author Affiliations +

Proceedings Volume 9467, Micro- and Nanotechnology Sensors, Systems, and Applications VII; 94670E (2015) https://doi.org/10.1117/12.2083508
Event: SPIE Defense + Security, 2015, Baltimore, MD, United States

Abstract

This paper describes a novel, wearable, battery powered ultrasound applicator that was evaluated as a therapeutic tool for healing of chronic wounds, such as venous ulcers. The low frequency and low intensity (~100mW/cm²) applicator works by generating ultrasound waves with peak-to-peak pressure amplitudes of 55 kPa at 20 kHz. The device was used in a pilot human study (n=25) concurrently with remote optical (diffuse correlation spectroscopy - DCS) monitoring to assess the healing outcome. More specifically, the ulcers’ healing status was determined by measuring tissue oxygenation and blood flow in the capillary network. This procedure facilitated an early prognosis of the treatment outcome and – once verified - may eventually enable customization of wound management. The outcome of the study shows that the healing patients of the ultrasound treated group had a statistically improved (p<0.05) average rate of wound healing (20.6%/week) compared to the control group (5.3%/week). In addition, the calculated blood flow index (BFI) decreased more rapidly in wounds that decreased in size, indicating a correlation between BFI and wound healing prediction. Overall, the results presented support the notion that active low frequency ultrasound treatment of chronic venous ulcers accelerates healing when combined with the current standard clinical care. The ultrasound applicator described here provides a user-friendly, fully wearable system that has the potential for becoming the first device suitable for treatment of chronic wounds in patient's homes, which - in turn - would increase patients’ compliance and improve quality of life.

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Christopher R. Bawiec, Youhan Sunny, David Diaz, Sumati Nadkarni, Michael S. Weingarten, Michael Neidrauer, David J. Margolis, Leonid Zubkov, and Peter A. Lewin "20 kHz ultrasound assisted treatment of chronic wounds with concurrent optic monitoring", Proc. SPIE 9467, Micro- and Nanotechnology Sensors, Systems, and Applications VII, 94670E (22 May 2015); https://doi.org/10.1117/12.2083508

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KEYWORDS

Ultrasonography

Wound healing

Blood circulation

Tissue optics

Tissues

Medicine

Diagnostics

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