EGFR-specific nanoprobe biodistribution in mouse models

Samia A. Fashir; Maiara L. Castilho; Michael A. Hupman; Christopher L. D. Lee; Leandro J. Raniero; Ian Alwayn; Kevin C. Hewitt

doi:10.1117/12.2180997

19 June 2015 EGFR-specific nanoprobe biodistribution in mouse models

Samia A. Fashir, Maiara L. Castilho, Michael A. Hupman, Christopher L. D. Lee, Leandro J. Raniero, Ian Alwayn, Kevin C. Hewitt

Author Affiliations +

Proceedings Volume 9531, Biophotonics South America; 95310E (2015) https://doi.org/10.1117/12.2180997
Event: SPIE Biophotonics South America, 2015, Rio de Janeiro, Brazil

Abstract

Nanotechnology offers a targeted approach to both imaging and treatment of cancer, the leading cause of death worldwide. Previous studies have found nanoparticles with a wide variety of coatings initiate an immune response leading to sequestration in the liver and spleen. In an effort to find a nanoparticle platform which does not elicit an immune response we created 43/44 nm gold or silver nanoparticles coated with biomolecules normally produced by the body, α-lipoic acid and the Epidermal Growth Factor (EGF), and have used mass spectroscopy to determine their biodistribution in mouse models, 24 hours following tail vein injection. Relative to controls, mouse EGF (mEGF) coated silver and gold nanoprobes are found at reduced levels in the liver and spleen. mEGF coated gold nanoprobes on the other hand do not appear to elicit any immune response, as they are found at background levels in these organs. As a result they should remain in circulation for longer and accumulate at high levels in tumors by the enhanced permeability retention (EPR) effect.

Citation Download Citation

Samia A. Fashir, Maiara L. Castilho, Michael A. Hupman, Christopher L. D. Lee, Leandro J. Raniero, Ian Alwayn, and Kevin C. Hewitt "EGFR-specific nanoprobe biodistribution in mouse models", Proc. SPIE 9531, Biophotonics South America, 95310E (19 June 2015); https://doi.org/10.1117/12.2180997

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