Preparation and optimization of aminolevulinic acid with gold nanoparticles for photothermal and photodynamic therapies applications

Karina de O. Gonçalves; Thiago da Silva Cordeiro; Flávia de Oliveira Silva; Ricardo E. Samad; Nilson D. Vieira Júnior; Lilia C. Courrol

doi:10.1117/12.2180017

19 June 2015 Preparation and optimization of aminolevulinic acid with gold nanoparticles for photothermal and photodynamic therapies applications

Karina de O. Gonçalves, Thiago da Silva Cordeiro, Flávia de Oliveira Silva, Ricardo E. Samad, Nilson D. Vieira Júnior, Lilia C. Courrol

Author Affiliations +

Proceedings Volume 9531, Biophotonics South America; 95314C (2015) https://doi.org/10.1117/12.2180017
Event: SPIE Biophotonics South America, 2015, Rio de Janeiro, Brazil

Abstract

The use of gold nanoparticles (AuNps) as the vehicle for 5-Aminolevulinic acid (ALA) delivery for photodynamic and photothermic plasmonic therapies is a promising approach, especially with the recent demonstration that this photosensitizer immobilization on the particle surface improves reactive oxygen species (ROS) formation, increasing its cytotoxicity. Gold nanorods (AuNRs) present an absorption spectrum shifted to 700 nm, within the tissue transparency window, which allows excitation of the nanoparticles situated deeper in the tissues. Here, we describe a new synthesis method that was applied to control the shape of the gold nanoparticles during its synthesis. To obtain ALA:AuNRs, precursor ALA:AuNps were irradiated by ultrashort laser pulses. The variation of the laser parameters such as pulse energy and duration and irradiation time was assessed. The relevant mechanisms are discussed.

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Karina de O. Gonçalves, Thiago da Silva Cordeiro, Flávia de Oliveira Silva, Ricardo E. Samad, Nilson D. Vieira Júnior, and Lilia C. Courrol "Preparation and optimization of aminolevulinic acid with gold nanoparticles for photothermal and photodynamic therapies applications", Proc. SPIE 9531, Biophotonics South America, 95314C (19 June 2015); https://doi.org/10.1117/12.2180017

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