Paper-based surfaced enhanced Raman spectroscopy for drug level testing with tear fluid

Kenji Yamada; Moe Yokoyama; Hieyong Jeong; Michiko Kido; Yuko Ohno

doi:10.1117/12.2192833

15 July 2015 Paper-based surfaced enhanced Raman spectroscopy for drug level testing with tear fluid

Kenji Yamada, Moe Yokoyama, Hieyong Jeong, Michiko Kido, Yuko Ohno

Proceedings Volume 9537, Clinical and Biomedical Spectroscopy and Imaging IV; 95372I (2015) https://doi.org/10.1117/12.2192833
Event: European Conferences on Biomedical Optics, 2015, Munich, Germany

Abstract

The purpose of this study was to show the effectiveness of therapeutic drug level testing by Paper-based Surfaced Enhanced Raman Spectroscopy (PSERS) for artificial lacrimal fluid. We have been used substrates which consist of a common filter paper and gold nano-rods. The targets were Phenobarbital (PB) which dissolved in artificial lacrimal fluid. We measured them using PSERS which the wavelength was 785nm, the power was 30mW. It was found that there were the strong peaks of PB at 997cm^-1 and 1026cm^-1 which corresponded with solid PB spectral peak for 1mM artificial lacrimal fluid. The results demonstrated the usefulness of this method. It is concluded that our method for therapeutic drug level testing is very efficient.

Citation Download Citation

Kenji Yamada, Moe Yokoyama, Hieyong Jeong, Michiko Kido, and Yuko Ohno "Paper-based surfaced enhanced Raman spectroscopy for drug level testing with tear fluid", Proc. SPIE 9537, Clinical and Biomedical Spectroscopy and Imaging IV, 95372I (15 July 2015); https://doi.org/10.1117/12.2192833

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