Modeling of the blood flow in the lower extremities for dynamic diffuse optical tomography of peripheral artery disease

A. Marone; J. W. Hoi; M. A. Khalil; H.K. Kim; G. Shrikhande; R. Dayal; A. H. Hielscher

doi:10.1117/12.2183948

16 July 2015 Modeling of the blood flow in the lower extremities for dynamic diffuse optical tomography of peripheral artery disease

A. Marone, J. W. Hoi, M. A. Khalil, H.K. Kim, G. Shrikhande, R. Dayal, A. H. Hielscher

Author Affiliations +

Proceedings Volume 9538, Diffuse Optical Imaging V; 95380Z (2015) https://doi.org/10.1117/12.2183948
Event: European Conferences on Biomedical Optics, 2015, Munich, Germany

Abstract

Peripheral Arterial Disease (PAD) is caused by a reduction of the internal diameters of the arteries in the upper or lower extremities mainly due to atherosclerosis. If not treated, its worsening may led to a complete occlusion, causing the death of the cells lacking proper blood supply, followed by gangrene that may require chirurgical amputation. We have recently performed a clinical study in which good sensitivities and specificities were achieved with dynamic diffuse optical tomography. To gain a better understanding of the physiological foundations of many of the observed effects, we started to develop a mathematical model for PAD. The model presented in this work is based on a multi-compartment Windkessel model, where the vasculature in the leg and foot is represented by resistors and capacitors, the blood pressure with a voltage drop, and the blood flow with a current. Unlike existing models, the dynamics induced by a thigh-pressure-cuff inflation and deflation during the measurements are taken into consideration. This is achieved by dynamically varying the resistances of the large veins and arteries. By including the effects of the thigh-pressure cuff, we were able to explain many of the effects observed during our dynamic DOT measurements, including the hemodynamics of oxy- and deoxy-hemoglobin concentration changes. The model was implemented in MATLAB and the simulations were normalized and compared with the blood perfusion obtained from healthy, PAD and diabetic patients. Our preliminary results show that in unhealthy patients the total system resistance is sensibly higher than in healthy patients.

Citation Download Citation

A. Marone, J. W. Hoi, M. A. Khalil, H.K. Kim, G. Shrikhande, R. Dayal, and A. H. Hielscher "Modeling of the blood flow in the lower extremities for dynamic diffuse optical tomography of peripheral artery disease", Proc. SPIE 9538, Diffuse Optical Imaging V, 95380Z (16 July 2015); https://doi.org/10.1117/12.2183948

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
6 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY

GET CITATION

RIGHTS & PERMISSIONS

Get copyright permission Get copyright permission on Copyright Marketplace

KEYWORDS

Arteries

Blood circulation

Blood

Data modeling

Veins

Mathematical modeling

Diffuse optical tomography

Show All Keywords

Keywords/Phrases

Search In:

Publication Years