Determination of the low concentration correction in the macroscopic singlet oxygen model for PDT

Michele M. Kim; Rozhin Penjweini; Jarod C. Finlay; Timothy C. Zhu

doi:10.1117/12.2213417

17 March 2016 Determination of the low concentration correction in the macroscopic singlet oxygen model for PDT

Michele M. Kim, Rozhin Penjweini, Jarod C. Finlay, Timothy C. Zhu

Proceedings Volume 9694, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXV; 96940D (2016) https://doi.org/10.1117/12.2213417
Event: SPIE BiOS, 2016, San Francisco, California, United States

Abstract

The macroscopic singlet oxygen model has been used for singlet oxygen explicit dosimetry in photodynamic therapy (PDT). The photophysical parameters for commonly used sensitizers, HPPH and BPD, have been investigated in pre-clinical studies using mouse models. So far, studies have involved optimizing fitting algorithms to obtain the some of the photophysical parameters (ξ, σ, g) and the threshold singlet oxygen dose ([¹O₂]_rx,sh), while other parameters such as the low concentration correction, δ, has been kept as a constant. In this study, using photobleaching measurements of mice in vivo, the value of δ was also optimized and fit to better describe experimental data. Furthermore, the value of the specific photobleaching ratio (σ) was also fine-tuned using the photobleaching results. Based on literature values of δ, σ for photosensitizers can be uniquely determined using the additional photobleaching measurements. This routine will further improve the macroscopic model of singlet oxygen production for use in explicit dosimetry.

Conference Presentation

Citation Download Citation

Michele M. Kim, Rozhin Penjweini, Jarod C. Finlay, and Timothy C. Zhu "Determination of the low concentration correction in the macroscopic singlet oxygen model for PDT", Proc. SPIE 9694, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXV, 96940D (17 March 2016); https://doi.org/10.1117/12.2213417

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