A closed-loop dual-modulation multi-spectral polarimeter for glucose monitoring

Zhen fang Yu; Casey W. Pirnstill; Gerard L. Coté

doi:10.1117/12.2211114

4 March 2016 A closed-loop dual-modulation multi-spectral polarimeter for glucose monitoring

Zhen fang Yu, Casey W. Pirnstill, Gerard L. Coté

Proceedings Volume 9715, Optical Diagnostics and Sensing XVI: Toward Point-of-Care Diagnostics; 97150U (2016) https://doi.org/10.1117/12.2211114
Event: SPIE BiOS, 2016, San Francisco, California, United States

Abstract

Optical polarimetry is a promising noninvasive means of assessing glucose concentration in the aqueous humor of the eye. One the major limiting factors is time-varying cornea birefringence due to motion artifact, which prevents the realization of this device. In this study, we simultaneously utilize laser intensity modulation and Faraday polarization rotation modulation for a real-time closed-loop multi-spectral polarimeter for glucose monitoring in vitro. In this report, a real-time closed-loop dual-modulation dual-spectral polarimeter was presented and in vitro glucose measurements were performed demonstrating the accuracy and repeatability of this polarimeter.

Citation Download Citation

Zhen fang Yu, Casey W. Pirnstill, and Gerard L. Coté "A closed-loop dual-modulation multi-spectral polarimeter for glucose monitoring", Proc. SPIE 9715, Optical Diagnostics and Sensing XVI: Toward Point-of-Care Diagnostics, 97150U (4 March 2016); https://doi.org/10.1117/12.2211114

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