Single molecule force spectroscopy study of y-polyglutamic acid by using atomic force microscopy

Parbhej Ahamed; Masaru Kawakami; Hidemitsu Furukawa

doi:10.1117/12.2218040

16 April 2016 Single molecule force spectroscopy study of γ-polyglutamic acid by using atomic force microscopy

Parbhej Ahamed, Masaru Kawakami, Hidemitsu Furukawa

Proceedings Volume 9802, Nanosensors, Biosensors, and Info-Tech Sensors and Systems 2016; 98020O (2016) https://doi.org/10.1117/12.2218040
Event: SPIE Smart Structures and Materials + Nondestructive Evaluation and Health Monitoring, 2016, Las Vegas, Nevada, United States

Abstract

γ-PGA is a versatile multi-functional biopolymer possessing much useful biological functionality. Each biological function is associated with specific properties related to various forms of γ-PGA. However, to date, knowledge about the molecular mechanism to control specific structures of γ-PGA under a certain environmental conditions are unknown. In this study, we used single molecule force spectroscopy (SMFS) method to characterize the structure of γ-PGA in two environmental conditions. A water environment or 0.5 M MgCl₂ salt solution was used to observe the effect of metal ion on γ-PGA structure at room temperature. The obtained results revealed that γ-PGA exists branched and/or cross-linked structure of γ-PGA in water or MgCl₂ salt solution.

Citation Download Citation

Parbhej Ahamed, Masaru Kawakami, and Hidemitsu Furukawa "Single molecule force spectroscopy study of γ-polyglutamic acid by using atomic force microscopy", Proc. SPIE 9802, Nanosensors, Biosensors, and Info-Tech Sensors and Systems 2016, 98020O (16 April 2016); https://doi.org/10.1117/12.2218040

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