Multifrequency high precise subTHz-THz-IR spectroscopy for exhaled breath research

Vladimir L. Vaks; Elena G. Domracheva; Sergey I. Pripolzin; Mariya B. Chernyaeva

doi:10.1117/12.2236686

26 September 2016 Multifrequency high precise subTHz-THz-IR spectroscopy for exhaled breath research

Vladimir L. Vaks, Elena G. Domracheva, Sergey I. Pripolzin, Mariya B. Chernyaeva

Proceedings Volume 9934, Terahertz Emitters, Receivers, and Applications VII; 99340E (2016) https://doi.org/10.1117/12.2236686
Event: SPIE Nanoscience + Engineering, 2016, San Diego, California, United States

Abstract

Nowadays the development of analytical spectroscopy with high performance, sensitivity and spectral resolution for exhaled breath research is attended. The method of two-frequency high precise THz spectroscopy and the method of high precise subTHz-THz-IR spectroscopy are presented. Development of a subTHz-THz-IR gas analyzer increases the number of gases that can be identified and the reliability of the detection by confirming the signature in both THz and MIR ranges. The testing measurements have testified this new direction of analytical spectroscopy to open widespread trends of its using for various problems of medicine and biology. First of all, there are laboratory investigations of the processes in exhaled breath and studying of their dynamics. Besides, the methods presented can be applied for detecting intermediate and short time living products of reactions in exhaled breath. The spectrometers have been employed for investigations of acetone, methanol and ethanol in the breath samples of healthy volunteers and diabetes patients. The results have demonstrated an increased concentration of acetone in breath of diabetes patients. The dynamic of changing the acetone concentration before and after taking the medicines is discovered. The potential markers of pre-cancer states and oncological diseases of gastrointestinal tract organs have been detected. The changes in the NO concentration in exhaled breath of cancer patients during radiotherapy as well as increase of the NH3 concentration at gastrointestinal diseases have been revealed. The preliminary investigations of biomarkers in three frequency ranges have demonstrated the advantages of the multifrequency high precise spectroscopy for noninvasive medical diagnostics.

Citation Download Citation

Vladimir L. Vaks, Elena G. Domracheva, Sergey I. Pripolzin, and Mariya B. Chernyaeva "Multifrequency high precise subTHz-THz-IR spectroscopy for exhaled breath research", Proc. SPIE 9934, Terahertz Emitters, Receivers, and Applications VII, 99340E (26 September 2016); https://doi.org/10.1117/12.2236686

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