Homemade prototype nasal probe for spectrally encoded interferometric microscopy (SEIM)

Zhikai Zhu; Lidek Chou; Asher Park; Brian J. F. Wong; Zhongping Chen

doi:10.1117/12.2609068

7 March 2022 Homemade prototype nasal probe for spectrally encoded interferometric microscopy (SEIM)

Zhikai Zhu, Lidek Chou, Asher Park, Brian J. F. Wong, Zhongping Chen

Proceedings Volume PC11935, Imaging, Therapeutics, and Advanced Technology in Head and Neck Surgery and Otolaryngology 2022; PC1193504 (2022) https://doi.org/10.1117/12.2609068
Event: SPIE BiOS, 2022, San Francisco, California, United States

Abstract

In human airway, the ciliated cells and mucus are the first line of defense against inhaled pathogens and particulates, preventing them from invading the rest of the respiratory system. Ciliary dysfunction can quickly develop into a vulnerability for patients with acute and/or chronic diseases, including cystic fibrosis, asthma, chronic obstructive pulmonary disease, and primary cilia dyskinesia. Ciliary beating frequency (CBF) can provide a good standard for determining cilia functionality. In this study, we developed a homemade prototype front-facing endoscope based on a spectrally encoded interferometric microscopy (SEIM) system using a phase-resolved Doppler (PRD) algorithm to measure and map the ciliary beating frequency within an en face region. We evaluated the capability of assessing the CBF ex vivo. This study is the steppingstone to in-vivo studies and the translation of mapping spatial CBF in clinics.

Conference Presentation

Citation Download Citation

Zhikai Zhu, Lidek Chou, Asher Park, Brian J. F. Wong, and Zhongping Chen "Homemade prototype nasal probe for spectrally encoded interferometric microscopy (SEIM) ", Proc. SPIE PC11935, Imaging, Therapeutics, and Advanced Technology in Head and Neck Surgery and Otolaryngology 2022, PC1193504 (7 March 2022); https://doi.org/10.1117/12.2609068

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