Evaluation of a high-performance FLIm/OCT catheter system for biochemical and structural evaluation of atherosclerosis

Julien Bec; Cai Li; Xiangnan Zhou; Deborah Vela; Laura Marcu

doi:10.1117/12.2607844

7 March 2022 Evaluation of a high-performance FLIm/OCT catheter system for biochemical and structural evaluation of atherosclerosis

Julien Bec, Cai Li, Xiangnan Zhou, Deborah Vela, Laura Marcu

Author Affiliations +

Proceedings Volume PC11936, Diagnostic and Therapeutic Applications of Light in Cardiology 2022; PC1193604 (2022) https://doi.org/10.1117/12.2607844
Event: SPIE BiOS, 2022, San Francisco, California, United States

Abstract

We report a novel multispectral FLIm/ swept-source OCT intravascular imaging catheter system including three key innovative features: 1) UV/NIR beam focusing is achieved with a free-form reflective distal optics that outperforms both ball and GRIN-based catheter optics, 2) stable optical coupling (single mode transmission: 75.7+-0.5% at 100 rps) by way of an air bearing rotary collimator, and 3) improvements in FLIm SNR obtained by integrating solid-state FLIm detection within the motor drive. Validation in excised human coronary artery specimens demonstrates the capabilities of FLIm to detect and quantify inflammation and characterize the extracellular matrix of atherosclerotic lesions.

Conference Presentation

Citation Download Citation

Julien Bec, Cai Li, Xiangnan Zhou, Deborah Vela, and Laura Marcu "Evaluation of a high-performance FLIm/OCT catheter system for biochemical and structural evaluation of atherosclerosis", Proc. SPIE PC11936, Diagnostic and Therapeutic Applications of Light in Cardiology 2022, PC1193604 (7 March 2022); https://doi.org/10.1117/12.2607844

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available