7 March 2022Lung parenchyma biomechanics in pulmonary fibrosis using endobronchial optical coherence tomography elastography imaging: a preliminary investigation
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Idiopathic pulmonary fibrosis (IPF) is a progressive, fatal type of interstitial lung disease (ILD) characterized by abnormal fibrotic scarring of lung parenchyma. We have demonstrated the use of endobronchial optical coherence tomography (EB-OCT) as a minimally-invasive approach for in vivo diagnosis of ILD in patients with high sensitivity and specificity. Here, we investigate the feasibility of EB-OCT elastography to measure the microscopic mechanical properties of normal and fibrotic lung parenchymal tissue in ex vivo porcine lung and in vivo in human subjects with ILD.
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