In-vivo airway compliance analysis of acute chlorine gas inhalation injury in rabbit model

Zhikai Zhu; George P. Philipopoulos; Melody Doosty; Jangwoen Lee; David Mukai; Xiao Gao; Sari B. Mahon; Matthew Brenner; Livia A. Veress; Carl W. White; Zhongping Chen

doi:10.1117/12.2610423

7 March 2022 In-vivo airway compliance analysis of acute chlorine gas inhalation injury in rabbit model

Zhikai Zhu, George P. Philipopoulos, Melody Doosty, Jangwoen Lee, David Mukai, Xiao Gao, Sari B. Mahon, Matthew Brenner, Livia A. Veress, Carl W. White, Zhongping Chen

Author Affiliations +

Proceedings Volume PC11937, Endoscopic Microscopy XVII; PC119370E (2022) https://doi.org/10.1117/12.2610423
Event: SPIE BiOS, 2022, San Francisco, California, United States

Abstract

In this work, we demonstrate the ability to image and quantify airway changes, we were able to quantify a decrease in airway compliance. The proposed approach will enable further investigations of using OCT assessing pulmonary injury to prevent/treat ARDS using a chlorine inhalation injury model, as well as diagnosing of large airway injury and compliance change due to airway toxic chemical exposure. With enhanced portability over conventional bronchoscopy, we believe our system is capable of field hospital deployment and investigating airway conditions in warfighters. Combining OCT and pressure transducer with bronchoscopy would enhance assessment and treatment of large airway chemical injury.

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Citation Download Citation

Zhikai Zhu, George P. Philipopoulos, Melody Doosty, Jangwoen Lee, David Mukai, Xiao Gao, Sari B. Mahon, Matthew Brenner, Livia A. Veress, Carl W. White, and Zhongping Chen "In-vivo airway compliance analysis of acute chlorine gas inhalation injury in rabbit model", Proc. SPIE PC11937, Endoscopic Microscopy XVII, PC119370E (7 March 2022); https://doi.org/10.1117/12.2610423

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KEYWORDS

In vivo imaging

Chlorine gas

Injuries

Imaging systems

Vertical cavity surface emitting lasers

Optical coherence tomography

Image segmentation

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