In vivo polarization sensitive endobronchial optical coherence tomography for microscopic imaging of fibrotic interstitial lung disease

Sreyankar Nandy; Sarita R. Berigei; Benjamin W. Roop; Arash Dadkah; Amita Sharma; Ashok Muniappan; Martin Villiger; Melissa J. Suter; Lida P. Hariri M.D.

doi:10.1117/12.2610296

7 March 2022 In vivo polarization sensitive endobronchial optical coherence tomography for microscopic imaging of fibrotic interstitial lung disease

Sreyankar Nandy, Sarita R. Berigei, Benjamin W. Roop, Arash Dadkah, Amita Sharma, Ashok Muniappan, Martin Villiger, Melissa J. Suter, Lida P. Hariri M.D.

Author Affiliations +

Proceedings Volume PC11937, Endoscopic Microscopy XVII; PC119370F (2022) https://doi.org/10.1117/12.2610296
Event: SPIE BiOS, 2022, San Francisco, California, United States

Abstract

Idiopathic pulmonary fibrosis (IPF) is a fatal form of interstitial lung disease (ILD), characterized by abnormal collagen deposition. Computed tomography imaging lacks the resolution to accurately distinguish and quantify fibrosis distribution at the microscopic level, and surgical biopsy methods are invasive. We demonstrate the feasibility of polarization sensitive endobronchial optical coherence tomography (PS EB-OCT) for quantitative in vivo microscopic assessment of fibrotic ILDs. PS EB-OCT was able to accurately distinguish fibrosis distribution patterns in IPF and non-IPF ILDs, independently compared against surgical biopsy. These findings support the potential of PS EB-OCT as a minimally-invasive method for assessment of ILD.

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Sreyankar Nandy, Sarita R. Berigei, Benjamin W. Roop, Arash Dadkah, Amita Sharma, Ashok Muniappan, Martin Villiger, Melissa J. Suter, and Lida P. Hariri M.D. "In vivo polarization sensitive endobronchial optical coherence tomography for microscopic imaging of fibrotic interstitial lung disease", Proc. SPIE PC11937, Endoscopic Microscopy XVII, PC119370F (7 March 2022); https://doi.org/10.1117/12.2610296

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