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7 March 2022 Assessing the skin pharmacokinetics of topical drugs using Raman spectroscopic tools
Richard H. Guy
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Proceedings Volume PC11938, Visualizing and Quantifying Drug Distribution in Tissue VI; PC1193805 (2022) https://doi.org/10.1117/12.2608145
Event: SPIE BiOS, 2022, San Francisco, California, United States
Abstract
Our research aims to demonstrate that Raman spectroscopy and imaging can provide a non-invasive, sensitive, and reproducible determination of the rate and extent at which a topically administered drug becomes available at its site of action in the skin. A key objective is to establish experimental methods, combining Raman spectroscopic tools with complementary calibration techniques and mathematical modelling, to prove this hypothesis ex vivo. The ultimate goal is to provide evidence that the routine, facile and non-invasive measurement of drug pharmacokinetics in the skin in vivo is achievable and has considerable potential for application in regulatory science and decision-making.
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Richard H. Guy "Assessing the skin pharmacokinetics of topical drugs using Raman spectroscopic tools", Proc. SPIE PC11938, Visualizing and Quantifying Drug Distribution in Tissue VI, PC1193805 (7 March 2022); https://doi.org/10.1117/12.2608145
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KEYWORDS
Raman spectroscopy
Skin
Imaging spectroscopy
Spectroscopes
Spectroscopy
Signal attenuation
Calibration
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