Chiral-field-enhanced Raman optical activity by a silicon nanodisk array

Tinghui Xiao; Zhengyi Luo; Kotaro Hiramatsu; Akihiro Isozaki; Tamitake Itoh; Zhenzhou Cheng; Masahiro Nomura; Satoshi Iwamoto; Keisuke Goda

doi:10.1117/12.2609277

7 March 2022 Chiral-field-enhanced Raman optical activity by a silicon nanodisk array

Tinghui Xiao, Zhengyi Luo, Kotaro Hiramatsu, Akihiro Isozaki, Tamitake Itoh, Zhenzhou Cheng, Masahiro Nomura, Satoshi Iwamoto, Keisuke Goda

Author Affiliations +

Proceedings Volume PC11957, Biomedical Vibrational Spectroscopy 2022: Advances in Research and Industry; PC119570P (2022) https://doi.org/10.1117/12.2609277
Event: SPIE BiOS, 2022, San Francisco, California, United States

Abstract

Raman optical activity (ROA) is a powerful tool for identifying the absolute conformational information and behavior of chiral molecules in aqueous solutions, but suffers from low sensitivity. Here we report our development of a silicon nanodisk array that tailors a chiral field to significantly increase the interaction between the excitation light and chiral molecules via exploiting a dark mode. Specifically, we used the array with pairs of chemical and biological enantiomers to show >100x enhanced chiral light-molecule interaction with negligible artifacts for ROA measurements. Our silicon nanodisk array opens a cost-effective way for conformational analysis of trace chiral molecules.

Conference Presentation

Citation Download Citation

Tinghui Xiao, Zhengyi Luo, Kotaro Hiramatsu, Akihiro Isozaki, Tamitake Itoh, Zhenzhou Cheng, Masahiro Nomura, Satoshi Iwamoto, and Keisuke Goda "Chiral-field-enhanced Raman optical activity by a silicon nanodisk array", Proc. SPIE PC11957, Biomedical Vibrational Spectroscopy 2022: Advances in Research and Industry, PC119570P (7 March 2022); https://doi.org/10.1117/12.2609277

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