Tumor-targeted photoacoustic imaging using dimerized cyanine-based contrast agent

Donghyeon Oh; Seunghyun Lee; Chulhong Kim

doi:10.1117/12.2608417

7 March 2022 Tumor-targeted photoacoustic imaging using dimerized cyanine-based contrast agent

Donghyeon Oh, Seunghyun Lee, Chulhong Kim

Proceedings Volume PC11960, Photons Plus Ultrasound: Imaging and Sensing 2022; PC119600N (2022) https://doi.org/10.1117/12.2608417
Event: SPIE BiOS, 2022, San Francisco, California, United States

Conference Poster

Abstract

In molecular photoacoustic imaging, the administration of an external photoacoustic contrast agent increases the photoacoustic yield and clarifies pathophysiological observation over the lesion site. Recognizing the necessity of a cyanine-based dye that complements the optical properties of ready-approved indocyanine green, we proceeded with molecular photoacoustic imaging in vitro and in vivo using cypate with a high absorption rate and photothermal conversion yield in the near-infrared I region. In addition, the particles are functionalized with tumor-avid peptide to facilitate receptor-based active delivery.

Conference Presentation

Citation Download Citation

Donghyeon Oh, Seunghyun Lee, and Chulhong Kim "Tumor-targeted photoacoustic imaging using dimerized cyanine-based contrast agent", Proc. SPIE PC11960, Photons Plus Ultrasound: Imaging and Sensing 2022, PC119600N (7 March 2022); https://doi.org/10.1117/12.2608417

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