Photoacoustic imaging of 3D-printed vascular models

Chenshuo Ma; Wanlu Li; Daiwei Li; Maomao Chen; Mian Wang; Laiming Jiang; Luis Santiago Mille; Carlos Ezio Garciamendez; Qifa Zhou; Yu Shrike Zhang; Junjie Yao

doi:10.1117/12.2608413

7 March 2022 Photoacoustic imaging of 3D-printed vascular models

Chenshuo Ma, Wanlu Li, Daiwei Li, Maomao Chen, Mian Wang, Laiming Jiang, Luis Santiago Mille, Carlos Ezio Garciamendez, Qifa Zhou, Yu Shrike Zhang, Junjie Yao

Author Affiliations +

Proceedings Volume PC11960, Photons Plus Ultrasound: Imaging and Sensing 2022; PC119601W (2022) https://doi.org/10.1117/12.2608413
Event: SPIE BiOS, 2022, San Francisco, California, United States

Abstract

Understanding thrombosis formation is necessary for developing safe and effective treatments. We fabricated sophisticated in vitro models of blood vessels with internal microchannels by using digital light processing-based 3D printing method. Photoacoustic microscopy (PAM) offers a useful platform for imaging 3D-printed vascular structures with different patterns of microchannels. Our results show that PAM can provide clear microchannel structures at depths up to 3.6 mm. We further quantified the blood oxygenation in the 3D-printed vascular models, showing that thrombi had much lower oxygenation than the normal blood. Integration of PAM with 3D printing/bioprinting will enable numerous applications in tissue engineering.

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Citation Download Citation

Chenshuo Ma, Wanlu Li, Daiwei Li, Maomao Chen, Mian Wang, Laiming Jiang, Luis Santiago Mille, Carlos Ezio Garciamendez, Qifa Zhou, Yu Shrike Zhang, and Junjie Yao "Photoacoustic imaging of 3D-printed vascular models", Proc. SPIE PC11960, Photons Plus Ultrasound: Imaging and Sensing 2022, PC119601W (7 March 2022); https://doi.org/10.1117/12.2608413

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