Phantoms with skin-mimicking layers of variable pigmentation level: characterizing impacts of melanin on photoacoustic imaging systems

William C. Vogt; Joshua Pfefer; Keith A. Wear; Brian S. Garra

doi:10.1117/12.2610013

7 March 2022 Phantoms with skin-mimicking layers of variable pigmentation level: characterizing impacts of melanin on photoacoustic imaging systems

William C. Vogt, Joshua Pfefer, Keith A. Wear, Brian S. Garra

Author Affiliations +

Proceedings Volume PC11960, Photons Plus Ultrasound: Imaging and Sensing 2022; PC119601Z (2022) https://doi.org/10.1117/12.2610013
Event: SPIE BiOS, 2022, San Francisco, California, United States

Abstract

Many applications of photoacoustic imaging (PAI) involve transdermal light delivery, and variable epidermal melanin content may be a potential confounding factor causing signal attenuation and imaging artifacts such as clutter. We developed polyvinyl chloride plastisol (PVCP) phantoms including epidermal and dermal layers. Skin phantoms were placed atop a breast-mimicking PVCP phantom to assess image quality. Nigrosin was added to epidermal layers to simulate Fitzpatrick Types I-VI and yielded a melanin-like spectral slope. Image quality testing indicated that higher pigmentation caused stronger clutter and reduced imaging depth. Phantom-based test methods may support evaluation of PAI device sensitivity to skin pigmentation variation.

Conference Presentation

Citation Download Citation

William C. Vogt, Joshua Pfefer, Keith A. Wear, and Brian S. Garra "Phantoms with skin-mimicking layers of variable pigmentation level: characterizing impacts of melanin on photoacoustic imaging systems", Proc. SPIE PC11960, Photons Plus Ultrasound: Imaging and Sensing 2022, PC119601Z (7 March 2022); https://doi.org/10.1117/12.2610013

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