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7 March 2022 Characterizing the biomechanical marker of intestinal fibrosis using endoscopic strain-photoacoustic imaging
Linyu Ni, Yunhao Zhu, Laura Johnson, Jonathan Rubin, Peter Higgins, Xueding Wang, Guan Xu
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Proceedings Volume PC11960, Photons Plus Ultrasound: Imaging and Sensing 2022; PC119602I (2022) https://doi.org/10.1117/12.2609774
Event: SPIE BiOS, 2022, San Francisco, California, United States
Abstract
Stiffness is a biomarker to distinguish intestinal inflammation and fibrosis in Crohn’s disease. This study investigated the performance of an endoscopic photoacoustic (PA)-ultrasound (US) catheter probe in quantifying intestinal stiffness in rabbits in vivo. The probe integrated a miniaturized US array and a side-firing fiber optic inside a medical balloon catheter. During the balloon dilation, the ratios between the intestinal wall deformation and PA signal change were quantified. The strain-PA ratios measured in vivo demonstrated a correlation of 0.8 (n=55, p=0.01) with the Young’s moduli of the assessed intestinal segments determined by microelastometry ex vivo.
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Linyu Ni, Yunhao Zhu, Laura Johnson, Jonathan Rubin, Peter Higgins, Xueding Wang, and Guan Xu "Characterizing the biomechanical marker of intestinal fibrosis using endoscopic strain-photoacoustic imaging", Proc. SPIE PC11960, Photons Plus Ultrasound: Imaging and Sensing 2022, PC119602I (7 March 2022); https://doi.org/10.1117/12.2609774
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KEYWORDS
Endoscopy
Intestine
Image segmentation
In vivo imaging
Inflammation
Photoacoustic spectroscopy
Transducers
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