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2 March 2022 Assessing structure-property relationship with Brillouin microscopy: multimodal optical imaging of cells and tissues.
Vladislav V. Yakovlev
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Proceedings Volume PC11962, Optical Elastography and Tissue Biomechanics VIV; PC1196206 (2022) https://doi.org/10.1117/12.2615779
Event: SPIE BiOS, 2022, San Francisco, California, United States
Abstract
Brillouin spectroscopy and microscopy is an emerging tool of biological imaging and biomedical spectroscopy, which allows assessing local viscoelastic properties of biological materials.One of the greatest untapped potentials of Brillouin microscopy is its compatibility with almost all known optical imaging modalities for multimodal optical imaging. In the past, we successfully demonstrated that Brillouin spectroscopy can be successfully combined with Raman spectroscopy for simultaneous imaging of local chemical and physical properties of cells and biomaterials. In this report, we describe our ongoing efforts to extend the multimodal capabilities of Brillouin microscopy for better understanding mechanical properties of biological systems and their relationship with the local structure, chemistry and metabolic activity.
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Vladislav V. Yakovlev "Assessing structure-property relationship with Brillouin microscopy: multimodal optical imaging of cells and tissues.", Proc. SPIE PC11962, Optical Elastography and Tissue Biomechanics VIV, PC1196206 (2 March 2022); https://doi.org/10.1117/12.2615779
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KEYWORDS
Imaging spectroscopy
Microscopy
Optical imaging
Optical microscopy
Tissues
Spectroscopy
Biomedical optics
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