Non-contact optical coherence elastography detects biomechanical changes in human cornea following UVA/riboflavin collagen cross linking

Mitchell A. Kirby; Ivan M. Pelivanov; John J. Pitre Jr.; Ryan T. Wallace; Matthew O'Donnell; Ruikang K. Wang; Tueng T. Shen

doi:10.1117/12.2609026

2 March 2022 Non-contact optical coherence elastography detects biomechanical changes in human cornea following UVA/riboflavin collagen cross linking

Mitchell A. Kirby, Ivan M. Pelivanov, John J. Pitre Jr., Ryan T. Wallace, Matthew O'Donnell, Ruikang K. Wang, Tueng T. Shen

Author Affiliations +

Proceedings Volume PC11962, Optical Elastography and Tissue Biomechanics VIV; PC119620S (2022) https://doi.org/10.1117/12.2609026
Event: SPIE BiOS, 2022, San Francisco, California, United States

Abstract

AμT-OCE was used to quantify changes in both the in-plane Young’s (E) and out-of-plane shear (G) moduli in human cornea following riboflavin/UVA crosslinking in a non-contact, non-destructive manner. Since OCT methods are broadly accepted in Ophthalmology, it suggests fast translation of AμT-OCE into clinical practice if results are confirmed in vivo. In addition, AμT-OCE can change diagnostic criteria of ectatic corneal diseases, leading to early diagnosis, reduced complications, customized surgical treatment, and new opportunities to develop personalized biomechanical models of the eye.

Conference Presentation

Citation Download Citation

Mitchell A. Kirby, Ivan M. Pelivanov, John J. Pitre Jr., Ryan T. Wallace, Matthew O'Donnell, Ruikang K. Wang, and Tueng T. Shen "Non-contact optical coherence elastography detects biomechanical changes in human cornea following UVA/riboflavin collagen cross linking", Proc. SPIE PC11962, Optical Elastography and Tissue Biomechanics VIV, PC119620S (2 March 2022); https://doi.org/10.1117/12.2609026

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