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2 March 2022 Fast analysis of virus-antibody interaction by common path interferometric microscopy
Samer Alhaddad, Houda Bey, Pascale Boulanger, Claude Boccara, , Ignacio Izeddin
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Proceedings Volume PC11972, Label-free Biomedical Imaging and Sensing (LBIS) 2022; PC1197210 (2022) https://doi.org/10.1117/12.2609444
Event: SPIE BiOS, 2022, San Francisco, California, United States
Abstract
Interferometric microscopy techniques have been recently developed to detect small particles at the nanoscale without the need for specific labeling. Here, we introduce a highly sensitive, label-free approach on a common path interferometric set-up working on a transmission that amplifies weak scattering signals coming from small particles. Using single-particle tracking analysis, we can track and differentiate viruses and other biotic particles in aquatic environment. Furthermore, we have developed a fast assay based on antibody recognition of targeted virus in solution. We associate changes in diffusion and in the interferometric signal of the detected particles with the immune reaction between antibodies and surface proteins of the virus.
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Samer Alhaddad, Houda Bey, Pascale Boulanger, Claude Boccara, , and Ignacio Izeddin "Fast analysis of virus-antibody interaction by common path interferometric microscopy", Proc. SPIE PC11972, Label-free Biomedical Imaging and Sensing (LBIS) 2022, PC1197210 (2 March 2022); https://doi.org/10.1117/12.2609444
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KEYWORDS
Interferometry
Nanoparticles
Microscopy
Viruses
Diffusion
Particles
Target recognition
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