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3 March 2022 Correction for background scattering dynamics in quantitative laser speckle contrast imaging
Shuqi Zheng, Lisa Kretsge, Alberto Cruz-Martín, Jerome Mertz
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Proceedings Volume PC11974, Biomedical Applications of Light Scattering XII; PC119740A (2022) https://doi.org/10.1117/12.2608356
Event: SPIE BiOS, 2022, San Francisco, California, United States
Abstract
When laser speckle contrast imaging (LSCI) is applied to in-vivo imaging in a mouse brain, the light scattering from tissue background is found to vary on millisecond time scales. Instead of treating background scattering as static, we present a method of LSCI analysis that fully incorporates the dynamics of background scattering. Fast and slow scattering components are distinguished by a method of clustering, enabling a determination of their relative weights. We further show that the speckle correlation time can be directly reconstructed rather than fitted to a model, thus achieving much faster processing speed.
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Shuqi Zheng, Lisa Kretsge, Alberto Cruz-Martín, and Jerome Mertz "Correction for background scattering dynamics in quantitative laser speckle contrast imaging", Proc. SPIE PC11974, Biomedical Applications of Light Scattering XII, PC119740A (3 March 2022); https://doi.org/10.1117/12.2608356
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KEYWORDS
Scattering
Laser speckle contrast imaging
Speckle
Laser scattering
Light scattering
Dynamic light scattering
Error analysis
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