Highly sensitive and specific SARS-CoV-2 serological assay using a magnetic modulation biosensing system

Shira Avivi Mintz; Yaniv Lustig; Victoria Indenbaum; Eli Schwartz; Amos Danielli

doi:10.1117/12.2613433

4 March 2022 Highly sensitive and specific SARS-CoV-2 serological assay using a magnetic modulation biosensing system

Shira Avivi Mintz, Yaniv Lustig, Victoria Indenbaum, Eli Schwartz, Amos Danielli

Proceedings Volume PC11979, Frontiers in Biological Detection: From Nanosensors to Systems XIV; PC1197906 (2022) https://doi.org/10.1117/12.2613433
Event: SPIE BiOS, 2022, San Francisco, California, United States

Abstract

The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to pose a global public health threat. Effective and rapid serological assays are needed to provide valuable information about acute and past viral infections. Using the receptor-binding domain of the SARS-CoV-2 spike protein 1 antigen and a highly sensitive detection technology, termed magnetic modulation biosensing (MMB), we demonstrate a quantitative and rapid SARS-CoV-2 IgG antibody test with high sensitivity and specificity compared with the gold standard ELISA test. The improved analytical and clinical sensitivity of the MMB-based assay can help clinical laboratories provide critical information in a timely manner and monitor the spread of the disease.

Conference Presentation

Citation Download Citation

Shira Avivi Mintz, Yaniv Lustig, Victoria Indenbaum, Eli Schwartz, and Amos Danielli "Highly sensitive and specific SARS-CoV-2 serological assay using a magnetic modulation biosensing system", Proc. SPIE PC11979, Frontiers in Biological Detection: From Nanosensors to Systems XIV, PC1197906 (4 March 2022); https://doi.org/10.1117/12.2613433

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