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The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to pose a global public health threat. Effective and rapid serological assays are needed to provide valuable information about acute and past viral infections. Using the receptor-binding domain of the SARS-CoV-2 spike protein 1 antigen and a highly sensitive detection technology, termed magnetic modulation biosensing (MMB), we demonstrate a quantitative and rapid SARS-CoV-2 IgG antibody test with high sensitivity and specificity compared with the gold standard ELISA test. The improved analytical and clinical sensitivity of the MMB-based assay can help clinical laboratories provide critical information in a timely manner and monitor the spread of the disease.
Shira Avivi Mintz,Yaniv Lustig,Victoria Indenbaum,Eli Schwartz, andAmos Danielli
"Highly sensitive and specific SARS-CoV-2 serological assay using a magnetic modulation biosensing system", Proc. SPIE PC11979, Frontiers in Biological Detection: From Nanosensors to Systems XIV, PC1197906 (4 March 2022); https://doi.org/10.1117/12.2613433
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Shira Avivi Mintz, Yaniv Lustig, Victoria Indenbaum, Eli Schwartz, Amos Danielli, "Highly sensitive and specific SARS-CoV-2 serological assay using a magnetic modulation biosensing system," Proc. SPIE PC11979, Frontiers in Biological Detection: From Nanosensors to Systems XIV, PC1197906 (4 March 2022); https://doi.org/10.1117/12.2613433