Mid-infrared lab-on-a-chip for protein sensing in real-time

Borislav Hinkov; Florian Pilat; Laurin Lux; Patricia L. Souza; Andreas Schwaighofer; Benedikt Schwarz; Hermann Detz; Aaron M. Andrews; Bettina Baumgartner; Bernhard Lendl; Gottfried Strasser; Mauro David

doi:10.1117/12.2610291

9 March 2022 Mid-infrared lab-on-a-chip for protein sensing in real-time

Borislav Hinkov, Florian Pilat, Laurin Lux, Patricia L. Souza, Andreas Schwaighofer, Benedikt Schwarz, Hermann Detz, Aaron M. Andrews, Bettina Baumgartner, Bernhard Lendl, Gottfried Strasser, Mauro David

Author Affiliations +

Proceedings Volume PC12021, Novel In-Plane Semiconductor Lasers XXI; PC120210M (2022) https://doi.org/10.1117/12.2610291
Event: SPIE OPTO, 2022, San Francisco, California, United States

Abstract

In this work we monolithically integrate a quantum cascade laser (QCL) and detector (QCD) addressing the same wavelengths lambda=1550-1650 cm-1 for liquid spectroscopy. QCL and QCD are combined using a 50-100 µm-long dielectric-loaded surface-plasmon-polariton (DLSPP) waveguide, which typically guides >>90% of the mode outside of the cavity. We show the analysis of the protein bovine serum albumin (BSA) and its denaturation process between 25°C-90°C in real time in a microfluidic cell (60 µl) for 20-60 mg/ml BSA-concentrations. To further test the sensor-robustness, we directly submerge it into a beaker and detect H2O up to 35%-40%, solved in isopropyl alcohol.

Conference Presentation

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Borislav Hinkov, Florian Pilat, Laurin Lux, Patricia L. Souza, Andreas Schwaighofer, Benedikt Schwarz, Hermann Detz, Aaron M. Andrews, Bettina Baumgartner, Bernhard Lendl, Gottfried Strasser, and Mauro David "Mid-infrared lab-on-a-chip for protein sensing in real-time", Proc. SPIE PC12021, Novel In-Plane Semiconductor Lasers XXI, PC120210M (9 March 2022); https://doi.org/10.1117/12.2610291

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