Biomimetic hierarchical surface micro- and nano-texturing of metals by femtosecond laser processing for the control of cell behavior

Miguel Martínez-Calderón; Miguel Manso-Silván; Ainara Rodríguez; Mikel Gómez-Aranzadi; Santiago M. Olaizola; Raúl J. Martín-Palma

doi:10.1117/12.2613358

18 April 2022 Biomimetic hierarchical surface micro- and nano-texturing of metals by femtosecond laser processing for the control of cell behavior

Miguel Martínez-Calderón, Miguel Manso-Silván, Ainara Rodríguez, Mikel Gómez-Aranzadi, Santiago M. Olaizola, Raúl J. Martín-Palma

Author Affiliations +

Proceedings Volume PC12041, Bioinspiration, Biomimetics, and Bioreplication XII; (2022) https://doi.org/10.1117/12.2613358
Event: SPIE Smart Structures + Nondestructive Evaluation, 2022, Long Beach, California, United States

Conference Poster

Abstract

Many physico-chemical properties shown by natural materials usually have their origin in a multi-scale, hierarchical structure based on a rather small selection of primary constituents. In fact, materials with wholly different properties are found in biological species just by spatially arranging their constituents at different length scales and in different ways. Within this context, the surface of stainless steel and titanium alloys was textured at the micro- and nano-scales aiming at using a hierarchical biomimetic approach to control cell attachment, proliferation, and migration. This approach has been followed based on the tremendous influence of the surface properties of biomaterials on the specific biological response of the surrounding tissues. In this regard, the precise control of the interaction between cells and the surface of materials allows tailoring and optimizing the performance of implants and prostheses integrated into the body. Different micro- and nano-structured surfaces were fabricated by femtosecond (fs) laser processing taking advantage of the fact that fs Laser Induced Periodical Surface Structures (LIPSS) nanopatterns are generated perpendicular to the laser beam polarization and therefore their orientation can be controlled. Various micro-/nano-pattern distributions and combinations were evaluated aiming at determining their influence in the cell culture viability, cell migration through the lines, and cell morphology.

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Miguel Martínez-Calderón, Miguel Manso-Silván, Ainara Rodríguez, Mikel Gómez-Aranzadi, Santiago M. Olaizola, and Raúl J. Martín-Palma "Biomimetic hierarchical surface micro- and nano-texturing of metals by femtosecond laser processing for the control of cell behavior", Proc. SPIE PC12041, Bioinspiration, Biomimetics, and Bioreplication XII, (18 April 2022); https://doi.org/10.1117/12.2613358

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