Removing skin micro-vessels using photo-mediated ultrasound therapy: a study on the chicken wattle model

Mingyang Wang; Rohit Singh; Yannis M. Paulus; Xinmai Yang; Xueding Wang

doi:10.1117/12.2650119

17 March 2023 Removing skin micro-vessels using photo-mediated ultrasound therapy: a study on the chicken wattle model

Mingyang Wang, Rohit Singh, Yannis M. Paulus, Xinmai Yang, Xueding Wang

Proceedings Volume PC12352, Photonics in Dermatology and Plastic Surgery 2023; PC123520H (2023) https://doi.org/10.1117/12.2650119
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

Cutaneous vascular malformations (CVM), such as port wine stain (PWS), often appear in highly visible parts of patient and cause emotional and social problems. In this work, we utilized our novel anti-vascular technique, termed photo-mediated ultrasound therapy (PUT), which combines nanosecond duration laser pulses synchronized with ultrasound bursts to treat blood vessels. The feasibility of PUT in the treatment of cutaneous microvessels was evaluated in a chicken wattle model in vivo. The treatment results showed perfusion stop in microvessels up to 1.5mm deep in chicken wattle, as demonstrated by both the OCT angiography and the color change in skin images after the treatment. The treatment effect and safety such as epidermal tissue damage and inflammation were also evaluated by H&E histology.

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Citation Download Citation

Mingyang Wang, Rohit Singh, Yannis M. Paulus, Xinmai Yang, and Xueding Wang "Removing skin micro-vessels using photo-mediated ultrasound therapy: a study on the chicken wattle model", Proc. SPIE PC12352, Photonics in Dermatology and Plastic Surgery 2023, PC123520H (17 March 2023); https://doi.org/10.1117/12.2650119

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KEYWORDS

Skin

Ultrasonography

In vivo imaging

Safety

Tissues

Angiography

Cavitation

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