Large area fractional laser treatment of mouse skin enhances the metabolic rate

Michael Wang-Evers; Nunciada Salma; Daniel Z. Karasik; Armen Yerevanian; Heather Downs; Tuanlian Luo; Dieter Manstein

doi:10.1117/12.2649996

17 March 2023 Large area fractional laser treatment of mouse skin enhances the metabolic rate

Michael Wang-Evers, Nunciada Salma, Daniel Z. Karasik, Armen Yerevanian, Heather Downs, Tuanlian Luo, Dieter Manstein

Author Affiliations +

Proceedings Volume PC12352, Photonics in Dermatology and Plastic Surgery 2023; PC123520J (2023) https://doi.org/10.1117/12.2649996
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

Large area fractional laser treatment (LAFLT) is a new fat removal and weight loss concept, which applies microscopic thermal injuries to large parts of the skin. These injuries induce a controlled metabolic response which temporarily increases the energy expenditure (EE), thereby reducing overall weight. In a mouse model, we investigated the dosimetry settings to induce this metabolic reaction. Therefore, mice were housed in metabolic cages and their body composition was analyzed. Results showed a significant EE increase (31% - 91%, p < 0.05) over a 6-day period which seems to suggest that an enhanced metabolic state can be achieved.

Conference Presentation

Citation Download Citation

Michael Wang-Evers, Nunciada Salma, Daniel Z. Karasik, Armen Yerevanian, Heather Downs, Tuanlian Luo, and Dieter Manstein "Large area fractional laser treatment of mouse skin enhances the metabolic rate", Proc. SPIE PC12352, Photonics in Dermatology and Plastic Surgery 2023, PC123520J (17 March 2023); https://doi.org/10.1117/12.2649996

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