Airway smooth muscle assessments with PS-OCT: Structure and function

David C. Adams; Melissa J. Suter

doi:10.1117/12.2652632

17 March 2023 Airway smooth muscle assessments with PS-OCT: Structure and function

David C. Adams, Melissa J. Suter

Proceedings Volume PC12356, Endoscopic Microscopy XVIII; PC1235605 (2023) https://doi.org/10.1117/12.2652632
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

Asthma is a widespread, potentially fatal disease characterized in part by airway smooth muscle (ASM) abnormality. In this work we present results using polarization sensitive optical coherence tomography (PS-OCT) to assess both ASM structure and function for the purpose of guiding treatment. We show imaging results from a longitudinal clinical study involving bronchial thermoplasty (BT) for the reduction of ASM, and we present our recent work on using a custom modified tissue bath apparatus to conduct imaging of airway segments in varied contractile states. By assessing both structure and function simultaneously, we could dramatically improve feedback obtained for prospective treatments.

Conference Presentation

Citation Download Citation

David C. Adams and Melissa J. Suter "Airway smooth muscle assessments with PS-OCT: Structure and function", Proc. SPIE PC12356, Endoscopic Microscopy XVIII, PC1235605 (17 March 2023); https://doi.org/10.1117/12.2652632

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