Early detection of Alzheimer’s disease in the human retina: insights of 7 years research

Benjamin Lochocki; Jurre den Haan; Frederique J. Hart de Ruyter; Maurice A. G. M. Kroon; E. Marleen Kemper; Charlotte E. Teunissen; Bart van Berckel; Aleid von de Kreeke; Philip Scheltens; Jeroen J. M. Hoozemans; Frank D. Verbraak; Femke H. Bouwman; Johannes F. de Boer

doi:10.1117/12.2648950

17 March 2023 Early detection of Alzheimer’s disease in the human retina: insights of 7 years research

Benjamin Lochocki, Jurre den Haan, Frederique J. Hart de Ruyter, Maurice A. G. M. Kroon, E. Marleen Kemper, Charlotte E. Teunissen, Bart van Berckel, Aleid von de Kreeke, Philip Scheltens, Jeroen J. M. Hoozemans, Frank D. Verbraak, Femke H. Bouwman, Johannes F. de Boer

Author Affiliations +

Proceedings Volume PC12360, Ophthalmic Technologies XXXIII; PC123601G (2023) https://doi.org/10.1117/12.2648950
Event: SPIE BiOS, 2023, San Francisco, California, United States

Conference Poster

Abstract

Current publications show promising results in the in-vivo detection of amyloid deposits in the retina of Alzheimer’s disease (AD) patients as well in post-mortem flat mounted retinal tissue. The results are promising for the detection of early alterations associated with AD. The aim of our study was to confirm recently published findings using almost identical methodology, blue (ex: λ = 486 nm) fluorescence retinal imaging, curcumin as labelling fluorophore, and a similar data analyzing process.

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Benjamin Lochocki, Jurre den Haan, Frederique J. Hart de Ruyter, Maurice A. G. M. Kroon, E. Marleen Kemper, Charlotte E. Teunissen, Bart van Berckel, Aleid von de Kreeke, Philip Scheltens, Jeroen J. M. Hoozemans, Frank D. Verbraak, Femke H. Bouwman, and Johannes F. de Boer "Early detection of Alzheimer’s disease in the human retina: insights of 7 years research", Proc. SPIE PC12360, Ophthalmic Technologies XXXIII, PC123601G (17 March 2023); https://doi.org/10.1117/12.2648950

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