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17 March 2023 Effects of long-term photobiomodulation on 5xFAD murine model of Alzheimer disease in a sham-controlled blind experiment study
Aleksander Sobolewski, Gaël Barthet, Hubert van den Bergh, Corinne Brana, Filipa Ferreira, Michalina Góra, George Kouvas, Salvatore Novello, Jules Scholler, Mélanie Sipion, Hilal Lashuel
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Proceedings Volume PC12362, Mechanisms of Photobiomodulation Therapy XVII; PC1236209 (2023) https://doi.org/10.1117/12.2649711
Event: SPIE BiOS, 2023, San Francisco, California, United States
Abstract
Near-infrared photobiomodulation has been reported to have therapeutic effects in several murine Alzheimer’s disease models. As a translational institution we sought to confirm and elaborate on these findings in a blind experiment study following GLP principles. 5xFAD mice were subjected to 810 nm transcutaneous LED photobiomodulation from one to six months of age with 0 (sham), 6 or 600 mW/cm2 power density. The effects - including dependence on light power values - were investigated with a battery of memory tests (novel object recognition, Y-maze and Morris water maze) and immunohistochemical and biochemical analyses (including ABeta plaque burden, neuronal count and inflammatory markers).
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Aleksander Sobolewski, Gaël Barthet, Hubert van den Bergh, Corinne Brana, Filipa Ferreira, Michalina Góra, George Kouvas, Salvatore Novello, Jules Scholler, Mélanie Sipion, and Hilal Lashuel "Effects of long-term photobiomodulation on 5xFAD murine model of Alzheimer disease in a sham-controlled blind experiment study", Proc. SPIE PC12362, Mechanisms of Photobiomodulation Therapy XVII, PC1236209 (17 March 2023); https://doi.org/10.1117/12.2649711
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KEYWORDS
Alzheimer's disease
Cameras
Collimation
Data analysis
Head
Image processing
Light emitting diodes
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