Variable oxygenation blood flow phantoms for calibration of spectral imaging techniques

Michaela Taylor-Williams; Graham Spicer; Sarah E. Bohndiek

doi:10.1117/12.2649809

17 March 2023 Variable oxygenation blood flow phantoms for calibration of spectral imaging techniques

Michaela Taylor-Williams, Graham Spicer, Sarah E. Bohndiek

Proceedings Volume PC12363, Multiscale Imaging and Spectroscopy IV; PC123630N (2023) https://doi.org/10.1117/12.2649809
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

Tissue-mimicking phantoms are vital for the calibration of imaging systems. Blood oxygenation is an important physiological parameter that spectral imaging devices can measure, motivating the need for blood phantoms with variable oxygenation. We present a soft lithography method for fabricating blood flow phantoms that enable control of channel size and blood oxygenation. Channel size was varied during the fabrication process. Oxygenation was varied by chemical oxygenation and deoxygenation of horse blood flowing in the phantom. The spectral properties of the phantoms were evaluated using a narrowband nailfold capillaroscopy system. The resulting phantoms yield a flexible approach for spectral imaging calibration.

Conference Presentation

Citation Download Citation

Michaela Taylor-Williams, Graham Spicer, and Sarah E. Bohndiek "Variable oxygenation blood flow phantoms for calibration of spectral imaging techniques", Proc. SPIE PC12363, Multiscale Imaging and Spectroscopy IV, PC123630N (17 March 2023); https://doi.org/10.1117/12.2649809

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