Bond-selective full-field optical coherence tomography

Haonan Zong; Celalettin Yurdakul; Jian Zhao; Zian Wang; Fukai Chen; M. Selim Ünlü; Ji-Xin Cheng

doi:10.1117/12.2652645

9 March 2023 Bond-selective full-field optical coherence tomography

Haonan Zong, Celalettin Yurdakul, Jian Zhao, Zian Wang, Fukai Chen, M. Selim Ünlü, Ji-Xin Cheng

Proceedings Volume PC12367, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVII; PC123670X (2023) https://doi.org/10.1117/12.2652645
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

Optical coherence tomography (OCT) has been a powerful 3D optical imaging tool in the last decade while it lacks molecular information. In this work, we integrate the mid-infrared photothermal microscopy with the OCT approach to demonstrate a bond-selective full-field optical coherence tomography (BS-FF-OCT), in which a pulsed mid-infrared laser is used to modulate the full-field OCT signal through the photothermal effect. This method achieves label-free volumetric infrared spectroscopic imaging at 1-μm isotropic resolution, demonstrated by a variety of samples, including 1 μm PMMA beads embedded in agarose gel, polypropylene fiber mattress, myelinated nerve bundle in mouse brain tissue, Caenorhabditis elegans, and cancer cell spheroids.

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Citation Download Citation

Haonan Zong, Celalettin Yurdakul, Jian Zhao, Zian Wang, Fukai Chen, M. Selim Ünlü, and Ji-Xin Cheng "Bond-selective full-field optical coherence tomography", Proc. SPIE PC12367, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVII, PC123670X (9 March 2023); https://doi.org/10.1117/12.2652645

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KEYWORDS

Optical coherence tomography

Mid-IR

3D image processing

FT-IR spectroscopy

Hyperspectral imaging

Image resolution

Imaging spectroscopy

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