Optical characterization of vascular health in sickle cell disease

Kathryn Jaroszynski; Timothy Quang; Julia Xu; Ingrid Frey; Elise Berning; Brian Hill; Swee Lay Thein; Bruce Tromberg

doi:10.1117/12.2650432

27 March 2023 Optical characterization of vascular health in sickle cell disease

Kathryn Jaroszynski, Timothy Quang, Julia Xu, Ingrid Frey, Elise Berning, Brian Hill, Swee Lay Thein, Bruce Tromberg

Author Affiliations +

Proceedings Volume PC12373, Optical Biopsy XXI: Toward Real-Time Spectroscopic Imaging and Diagnosis; PC123730L (2023) https://doi.org/10.1117/12.2650432
Event: SPIE BiOS, 2023, San Francisco, California, United States

Conference Poster

Abstract

Sickle Cell Disease (SCD) is an inherited hemoglobin disorder associated with multiple organ damage caused by continuous inflammation and systemic vasculopathy. There is a need for comprehensive technologies that can characterize vascular hemodynamics at the bedside. Near-infrared spectroscopy (NIRS) techniques show promise as a non-invasive diagnostic tool for monitoring tissue hemodynamics. Subjects with SCD were recruited to undergo longitudinal optical measurements while participating in a long-term efficacy study of Mitapivat, a pyruvate kinase activator under clinical development. We demonstrate the sensitivity of multiple modalities to hemodynamic changes in patients that achieved a < 1g/dL increase in hemoglobin level.

Citation Download Citation

Kathryn Jaroszynski, Timothy Quang, Julia Xu, Ingrid Frey, Elise Berning, Brian Hill, Swee Lay Thein, and Bruce Tromberg "Optical characterization of vascular health in sickle cell disease", Proc. SPIE PC12373, Optical Biopsy XXI: Toward Real-Time Spectroscopic Imaging and Diagnosis, PC123730L (27 March 2023); https://doi.org/10.1117/12.2650432

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