Visualization of the sub-micron structure of scattering objects with nano-sensitivity

Sergey A. Alexandrov; Anand Arangath; Rajib Day; Ryan McAuley; Martin Leahy

doi:10.1117/12.2658015

7 March 2023 Visualization of the sub-micron structure of scattering objects with nano-sensitivity

Sergey A. Alexandrov, Anand Arangath, Rajib Day, Ryan McAuley, Martin Leahy

Proceedings Volume PC12378, Dynamics and Fluctuations in Biomedical Photonics XX; PC123780C (2023) https://doi.org/10.1117/12.2658015
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

At the early onset of a disease, the morphological changes manifest themselves on a cellular level (submicron scale). Label-free detection of nano-scale structural changes in sub-micron structure poses a significant challenge to researchers. A nano-sensitive OCT (nsOCT) technique permits to visualize 3D structure with nano-sensitivity to structural changes. Here, we present a brief theory and further development of the nsOCT approach, demonstrate different imaging modalities and unique abilities by monitoring internal nano-scale structural changes within different objects, including human skin in vivo. The presented results show new possibilities for study of structural changes, without the need for biomarkers or labels.

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Sergey A. Alexandrov, Anand Arangath, Rajib Day, Ryan McAuley, and Martin Leahy "Visualization of the sub-micron structure of scattering objects with nano-sensitivity", Proc. SPIE PC12378, Dynamics and Fluctuations in Biomedical Photonics XX, PC123780C (7 March 2023); https://doi.org/10.1117/12.2658015

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KEYWORDS

Visualization

Optical coherence tomography

Scattering

Biomedical optics

Biophysics

Computer programming

In vivo imaging

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