Single-chain nanoparticles as contrast agents for photoacoustic pump-probe imaging

Guo Tang; Justus Friedrich Thuemmler; Farzin Golmohamadi; Franz-Josef Schmitt; Wolfgang Binder; Jan Laufer

doi:10.1117/12.2649972

9 March 2023 Single-chain nanoparticles as contrast agents for photoacoustic pump-probe imaging

Guo Tang, Justus Friedrich Thuemmler, Farzin Golmohamadi, Franz-Josef Schmitt, Wolfgang Binder, Jan Laufer

Proceedings Volume PC12379, Photons Plus Ultrasound: Imaging and Sensing 2023; PC123790Q (2023) https://doi.org/10.1117/12.2649972
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

Polymer-based nanoparticles are promising contrast agents for photoacoustic (PA) imaging as their properties can be tailored to maximize detection sensitivity against the overwhelming endogenous background, while pump-probe excitation and fluence-dependent image acquisition may provide alternative approaches for contrast agent detection instead of multispectral imaging and unmixing. In this study, PA signals were measured in single-chain nanoparticle (SCNP) suspensions at pump and probe wavelengths of 690 nm and 730 nm and showed a strong nonlinear fluence dependence, which provides a unique contrast mechanism for molecular PA imaging.

Conference Presentation

Citation Download Citation

Guo Tang, Justus Friedrich Thuemmler, Farzin Golmohamadi, Franz-Josef Schmitt, Wolfgang Binder, and Jan Laufer "Single-chain nanoparticles as contrast agents for photoacoustic pump-probe imaging", Proc. SPIE PC12379, Photons Plus Ultrasound: Imaging and Sensing 2023, PC123790Q (9 March 2023); https://doi.org/10.1117/12.2649972

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