Multimodal functional optoacoustic tomography in awake and anesthetized mice

Sarah Shaykevich; Russell W. Chan; Justin P. Little; Daniel Razansky; Kevin C. Chan; Shy Shoham

doi:10.1117/12.2650939

9 March 2023 Multimodal functional optoacoustic tomography in awake and anesthetized mice

Sarah Shaykevich, Russell W. Chan, Justin P. Little, Daniel Razansky, Kevin C. Chan, Shy Shoham

Proceedings Volume PC12379, Photons Plus Ultrasound: Imaging and Sensing 2023; PC123791F (2023) https://doi.org/10.1117/12.2650939
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

Optoacoustic tomography (OAT) in the first near infrared window (NIR I) can capture much of the mouse brain with high temporal and spatial (mesoscale) resolutions, making it an excellent candidate for functional neuroimaging studies. Here, we introduce and demonstrate two complementary advances in this emerging technology: functional OAT neuro-imaging in awake, head-fixed mice and simultaneous imaging of the real time dynamics of both the vascular and glymphatic systems. We demonstrate our system’s new capabilities by imaging functional responses to odor stimuli throughout the olfactory system and characterizing brain-wide clearance dynamics.

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Citation Download Citation

Sarah Shaykevich, Russell W. Chan, Justin P. Little, Daniel Razansky, Kevin C. Chan, and Shy Shoham "Multimodal functional optoacoustic tomography in awake and anesthetized mice", Proc. SPIE PC12379, Photons Plus Ultrasound: Imaging and Sensing 2023, PC123791F (9 March 2023); https://doi.org/10.1117/12.2650939

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KEYWORDS

Optoacoustics

Near infrared

Tomography

Brain

Hemodynamics

Imaging systems

Multispectral imaging

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