Combined ultraviolet confocal reflectance and photoacoustic remote sensing microscopy for generating virtual sectioned histology

Nathaniel J. M. Haven; Matthew Martell; Jean Deschenes; Lashan Peiris; Nadia Giannakopoulos; Roger Zemp

doi:10.1117/12.2650881

9 March 2023 Combined ultraviolet confocal reflectance and photoacoustic remote sensing microscopy for generating virtual sectioned histology

Nathaniel J. M. Haven, Matthew Martell, Jean Deschenes, Lashan Peiris, Nadia Giannakopoulos, Roger Zemp

Author Affiliations +

Proceedings Volume PC12379, Photons Plus Ultrasound: Imaging and Sensing 2023; PC123791T (2023) https://doi.org/10.1117/12.2650881
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

Histological analysis of tissues is the current gold standard utilized by pathologists in reviewing excised tumor specimen margins. However, as a result of time-consuming and labor-intensive pre-processing steps this approach leads to postponed post-operative feedback to surgeons resulting in worsened patient prognosis. In this work we introduce a combined ultraviolet confocal reflectance and photoacoustic remote sensing microscopy system that allows tightly optically sectioned high-resolution virtual histology imaging of freshly excised thick tissues label-free. By removing tissue preparation steps, this technique has real potential to translate post-operative feedback into the surgical suite.

Conference Presentation

Citation Download Citation

Nathaniel J. M. Haven, Matthew Martell, Jean Deschenes, Lashan Peiris, Nadia Giannakopoulos, and Roger Zemp "Combined ultraviolet confocal reflectance and photoacoustic remote sensing microscopy for generating virtual sectioned histology", Proc. SPIE PC12379, Photons Plus Ultrasound: Imaging and Sensing 2023, PC123791T (9 March 2023); https://doi.org/10.1117/12.2650881

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available