Cervical collagen and elastic fibers classification with Mueller matrix polarimetry (Conference Presentation)

Ajmal Ajmal; Tananant Boonya-Ananta; Jessica C. Ramella-Roman

doi:10.1117/12.2657297

15 March 2023 Cervical collagen and elastic fibers classification with Mueller matrix polarimetry (Conference Presentation)

Ajmal Ajmal, Tananant Boonya-Ananta, Jessica C. Ramella-Roman

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Proceedings Volume PC12382, Polarized Light and Optical Angular Momentum for Biomedical Diagnostics 2023; PC123820B (2023) https://doi.org/10.1117/12.2657297
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

The uterine cervix is composed mainly of fibrous connective tissues where collagen and glycosaminoglycans are the main components. Recent work has shown that elastic fibers also contribute to the cervix's change in mechanical function during pregnancy. While cervical collagen can be visualized with non-linear optical techniques, elastic fibers cannot be uniquely identified without an extensive staining protocol. Here we propose the development of a compound Mueller Matrix microscope to image Mice cervices at different gestation points and visualize collagen and elastic fibers using a convolutional neural network (CNN) and K-nearest neighbor (K-NN) classifiers. The study demonstrates a new methodology for classifying collagen and elastic fibers in the uterine cervix that can be applied to any Mueller Matrix polarimeter once initial calibration is conducted.

Conference Presentation

Citation Download Citation

Ajmal Ajmal, Tananant Boonya-Ananta, and Jessica C. Ramella-Roman "Cervical collagen and elastic fibers classification with Mueller matrix polarimetry (Conference Presentation)", Proc. SPIE PC12382, Polarized Light and Optical Angular Momentum for Biomedical Diagnostics 2023, PC123820B (15 March 2023); https://doi.org/10.1117/12.2657297

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KEYWORDS

Collagen

Optical fibers

Polarimetry

Cervix

Visualization

Nonlinear optics

Second-harmonic generation

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