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16 March 2023 Prostate needle biopsy metabolic analysis and virtual H&E microscopy using photoacoustic remote sensing and autofluorescence microscopy (Conference Presentation)
Brendon S. Restall, Brendyn D. Cikaluk, Matthew M. Martell, Nathaniel J. M. Haven, Adam Kinnaird, Roger J. Zemp
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Proceedings Volume PC12391, Label-free Biomedical Imaging and Sensing (LBIS) 2023; PC123910P (2023) https://doi.org/10.1117/12.2650688
Event: SPIE BiOS, 2023, San Francisco, California, United States
Abstract
We present photoacoustic remote sensing and autofluorescence microscopy with surface excitation (PARS-AMUSE) system that combines several methodologies of optical imaging including absorption, scattering and radiative emission. We generate virtual hematoxylin and eosin (H&E) images from absorption and scattering data using a generative adversarial network for margin assessment and cancer grading with simultaneous metabolic measurements from the autofluorescence of NADH and FAD. This system utilizes a single excitation source for all three imaging modalities to minimize complexity and cost. Using this system, we aim to profile specific cancers and predict cancer aggression.
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Brendon S. Restall, Brendyn D. Cikaluk, Matthew M. Martell, Nathaniel J. M. Haven, Adam Kinnaird, and Roger J. Zemp "Prostate needle biopsy metabolic analysis and virtual H&E microscopy using photoacoustic remote sensing and autofluorescence microscopy (Conference Presentation)", Proc. SPIE PC12391, Label-free Biomedical Imaging and Sensing (LBIS) 2023, PC123910P (16 March 2023); https://doi.org/10.1117/12.2650688
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KEYWORDS
Microscopy
Biopsy
Photoacoustic spectroscopy
Remote sensing
Biological research
Prostate
Cancer
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