Activatable Raman probes for multiplexed imaging of biological phenomena (Conference Presentation)

Mako Kamiya

doi:10.1117/12.2648638

15 March 2023 Activatable Raman probes for multiplexed imaging of biological phenomena (Conference Presentation)

Mako Kamiya

Proceedings Volume PC12392, Advanced Chemical Microscopy for Life Science and Translational Medicine 2023; PC1239206 (2023) https://doi.org/10.1117/12.2648638
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

Raman probes based on alkyne or nitrile tags hold promise for highly multiplexed imaging. In order to functionalize the Raman probes to trace biological phenomena in live cells, we have established a general strategy to control Raman signal intensity based on the resonant Raman effect, and prepared activatable Raman probes that show enhanced Raman signals upon reaction with enzymes under physiological conditions. Recently, we expanded our molecular design strategy by developing aggregation-based Raman probes for detecting enzyme activities in tissues, photo-activatable Raman probes, and photo-switchable Raman probes for super-resolution Raman imaging.

Conference Presentation

Citation Download Citation

Mako Kamiya "Activatable Raman probes for multiplexed imaging of biological phenomena (Conference Presentation)", Proc. SPIE PC12392, Advanced Chemical Microscopy for Life Science and Translational Medicine 2023, PC1239206 (15 March 2023); https://doi.org/10.1117/12.2648638

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