High-content stimulated Raman scattering histology of breast cancer (Conference Presentation)

Hongli Ni; Chinmayee V. Prabhu Dessai; Haonan Lin; Wei Wang; Ji-Xin Cheng

doi:10.1117/12.2647204

15 March 2023 High-content stimulated Raman scattering histology of breast cancer (Conference Presentation)

Hongli Ni, Chinmayee V. Prabhu Dessai, Haonan Lin, Wei Wang, Ji-Xin Cheng

Proceedings Volume PC12392, Advanced Chemical Microscopy for Life Science and Translational Medicine 2023; PC123920E (2023) https://doi.org/10.1117/12.2647204
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

Breast cancer is one of the most common cancers among women worldwide. The process of diagnosis is completed with conventional histology (Hematoxylin and eosin staining followed by immunohistochemistry staining), which is known to be labor-intensive, time-consuming, and subject to inter- as well as intra-laboratory variations. We present here a multi-color Stimulated Raman Histology (SRH) technique to overcome these limitations. The multi-color SRH can map lipid, cellular protein, and collagen in a label-free manner to differentiate cancerous breast tissue from healthy tissue. Our technique can be a promising candidate for labor-efficient, fast, and highly sensitive breast cancer histology.

Conference Presentation

Citation Download Citation

Hongli Ni, Chinmayee V. Prabhu Dessai, Haonan Lin, Wei Wang, and Ji-Xin Cheng "High-content stimulated Raman scattering histology of breast cancer (Conference Presentation)", Proc. SPIE PC12392, Advanced Chemical Microscopy for Life Science and Translational Medicine 2023, PC123920E (15 March 2023); https://doi.org/10.1117/12.2647204

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