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17 March 2023 Hollow porous platinum-based nanocomposite for combined tumor therapy (Conference Presentation)
Jingyu Sun, Shang Wang, Hongjun Wang
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Proceedings Volume PC12395, Colloidal Nanoparticles for Biomedical Applications XVIII; PC123950B (2023) https://doi.org/10.1117/12.2651012
Event: SPIE BiOS, 2023, San Francisco, California, United States
Abstract
A hollow porous platinum nanostructure was synthesized using a novel silver-micelle combined dual template method. Such nanoparticles enabled photothermal therapy of cancers with near-infrared second window (NIR-II). Because of the unique hollow core and porous shell structure, drastically increased loading capacity was achieved with anti-tumor therapeutics. Furthermore, the high catalysis efficiency of platinum porous shell could effectively catalyze the decomposition of endogenous H2O2 into O2 to relieve the tumorous hypoxia microenvironment and consequently enhance the therapeutic efficiency. Apparently, the hollow porous platinum nanostructures endow the possibility of treating tumors with multimodal imaging-guided NIR-II photothermal therapy in combination with other therapies.
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Jingyu Sun, Shang Wang, and Hongjun Wang "Hollow porous platinum-based nanocomposite for combined tumor therapy (Conference Presentation)", Proc. SPIE PC12395, Colloidal Nanoparticles for Biomedical Applications XVIII, PC123950B (17 March 2023); https://doi.org/10.1117/12.2651012
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KEYWORDS
Tumors
Platinum
Nanocomposites
Nanostructures
Absorption
Nanoparticles
Scattering
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