Real-time monitoring of tissue chips via integrated photonic sensors (Conference Presentation)

Benjamin L. Miller; John Cognetti; Maya Moen

doi:10.1117/12.2657458

17 March 2023 Real-time monitoring of tissue chips via integrated photonic sensors (Conference Presentation)

Benjamin L. Miller, John Cognetti, Maya Moen

Proceedings Volume PC12397, Frontiers in Biological Detection: From Nanosensors to Systems XV; PC1239701 (2023) https://doi.org/10.1117/12.2657458
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

Advanced in vitro microfluidic tissue models, deemed “tissue chips” or “organs-on-chips”, seek to replicate the complexity of living organisms in a low-cost format suitable for high-throughput experimentation. To date, most such systems have relied on destructive techniques such as immunofluorescence microscopy, or downstream analysis of fluid in the microfluidic path, to report on the activity of the tissue chip under study. In order to provide real-time monitoring capability for tissue chips, we initiated a program to integrate photonic sensors (ring resonators fabricated in silicon nitride) in close proximity to the tissue under study. To date we have succeeded in developing a microfluidic device containing both a nanoporous membrane chip for suspended cell culture, along with a multiplex, antibody-functionalized ring resonator-based photonic sensor chip.

Conference Presentation

Citation Download Citation

Benjamin L. Miller, John Cognetti, and Maya Moen "Real-time monitoring of tissue chips via integrated photonic sensors (Conference Presentation)", Proc. SPIE PC12397, Frontiers in Biological Detection: From Nanosensors to Systems XV, PC1239701 (17 March 2023); https://doi.org/10.1117/12.2657458

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KEYWORDS

Sensors

Tissue optics

Integrated photonics

Microfluidics

Photodetectors

Tissues

Resonators

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