Opportunities for biosensing with fluorescent diamond and phosphor nanoparticles

Philip R. Hemmer

doi:10.1117/12.2657357

9 March 2023 Opportunities for biosensing with fluorescent diamond and phosphor nanoparticles

Philip R. Hemmer

Proceedings Volume PC12447, Quantum Sensing, Imaging, and Precision Metrology; PC124470M (2023) https://doi.org/10.1117/12.2657357
Event: SPIE Quantum West, 2023, San Francisco, California, United States

Abstract

Diamond and phosphor nanoparticles can probe biological processes on the nanoscale, sometimes with the potential for quantum-enhanced sensing. However, there are issues that must be addressed to enable widespread application. For example, in the case of magnetic sensing it is desirable to have as many nitrogen-vacancy (NV) color center as possible. Yet leftover nitrogen atoms are a source of spin noise that rapidly degrades magnetic sensitivity. In the case of phosphor nanoparticles, the ubiquitous biofluorescence background can be suppressed by upconversion in rare earth doped crystals, even for excitation laser intensities comparable to single-photon transitions. However these optical transitions have a relatively low quantum efficiency per ion. In this talk I will discuss new approaches toward solving these problems by combining both technologies, for example, heterogeneous core-shell structures involving both diamond and phosphor nanoparticles.

Conference Presentation

Citation Download Citation

Philip R. Hemmer "Opportunities for biosensing with fluorescent diamond and phosphor nanoparticles", Proc. SPIE PC12447, Quantum Sensing, Imaging, and Precision Metrology, PC124470M (9 March 2023); https://doi.org/10.1117/12.2657357

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