Detecting Barrett’s esophagus using a methylene blue fluorescent slurry and a multi-modal optical coherence tomography and fluorescence capsule

Andrew D. Thrapp; Evaggelia Gavgiotakis; Joseph A. Gardecki; Andreas Wartak; Catriona N. Grant; Guillermo J. Tearney

doi:10.1117/12.3008546

13 March 2024 Detecting Barrett’s esophagus using a methylene blue fluorescent slurry and a multi-modal optical coherence tomography and fluorescence capsule

Andrew D. Thrapp, Evaggelia Gavgiotakis, Joseph A. Gardecki, Andreas Wartak, Catriona N. Grant, Guillermo J. Tearney

Author Affiliations +

Proceedings Volume PC12820, Endoscopic Microscopy XIX; PC1282006 (2024) https://doi.org/10.1117/12.3008546
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

We conducted a first-in-human study using a fluorescent slurry comprised of 10 ml Methylene Blue (50 mg dissolved in water) and 10 ml Agave nectar. Preliminary data from the first patient indicates that at 20 minutes Barrett's Esophagus (esophageal pre-cancer) can be discriminated from normal tissue with a target-to-background ratio of 1.96 and an effect size > 5 (Cohen's D). We further show a dose modification pathway to high-TBR imaging shortly after swallowing the slurry.

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Andrew D. Thrapp, Evaggelia Gavgiotakis, Joseph A. Gardecki, Andreas Wartak, Catriona N. Grant, and Guillermo J. Tearney "Detecting Barrett’s esophagus using a methylene blue fluorescent slurry and a multi-modal optical coherence tomography and fluorescence capsule", Proc. SPIE PC12820, Endoscopic Microscopy XIX, PC1282006 (13 March 2024); https://doi.org/10.1117/12.3008546

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